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Monoclonal B-cell lymphocytosis (MBL) is a condition that resembles chronic lymphocytic leukemia (CLL), but does not meet the criteria for CLL, and does not require treatment. However, CLL requiring treatment develops at the rate of 1.1% per year.〔(Rawstron, N Engl J Med 359:575 )〕〔(Monoclonal B-Cell Lymphocytosis Progresses to Leukemia in Some Patients ), Roxanne Nelson, Medscape Medical News, Aug. 7, 2008〕 The definition of CLL includes >5,000 CLL-phenotype B-cell lymphocytes per cubic millimeter. Patients with <5,000 (but not 0) CLL-phenotype B-cell lymphocytes per mm³, and no symptoms of CLL, are diagnosed with MBL. The term monoclonal means that all the B cells are derived from a single cell. ==Causes== Little is yet known about the causes of MBL, but as it is a ''forme fruste'' of CLL the etiologies of these two conditions would be closely related. Genetic changes that can be found in CLL have also been found in MBL, and relatives of people with CLL have a much higher chance of having MBL (13% of first-degree relatives in one study). One concern about MBL is related to blood transfusions. MBL was found in 0.14% of blood donors in one study. It is unknown whether blood transfusion can transmit MBL.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Monoclonal B-cell lymphocytosis」の詳細全文を読む スポンサード リンク
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